isoform

Definitions

Any of several different forms of the same protein, arising from either single nucleotide polymorphisms, differential splicing of mRNA, or post-translational modifications (e.g. sulfation, glycosylation, etc.)

Equivalents

Examples

“Intriguingly, the rat C1b isoform of the calcitonin receptor (CTR) (see⟳ Section VI-B) has very little interaction with the thyroidally derived form⟳ of calcitonin.”

“This can be demonstrated in NOD mice in which a point⟳ mutation in the autoimmune regulator (Aire) gene results in the reduced expression of P0 in the thymus and a concomitant increase⟳ of P0 specific T cells in the periphery. 107 Similarly, autoimmunity is shifted towards the peripheral nerve in another NOD model⟳ deficient for isoforms of ICAM-1. 108 Altered expression of ICAM-1 on thymic epithelial cells transforms selection of T cells from a diabetogenic into a neuritogenic repertoire. 108 Studies such as these highlight the critical role of regulatory mechanisms in maintaining immune homeostasis and the impact that changes to regulation can have⟳ on the development of disease.”

CEFR level