autoimmunity

Definitions

The condition where one's immune system attacks one's own tissues, i.e., an autoimmune disorder.

countable, uncountable

Equivalents

Examples

“This can be demonstrated in NOD mice in which a point⟳ mutation in the autoimmune regulator (Aire) gene results in the reduced expression of P0 in the thymus and a concomitant increase⟳ of P0 specific T cells in the periphery. 107 Similarly, autoimmunity is shifted towards the peripheral nerve in another NOD model⟳ deficient for isoforms of ICAM-1. 108 Altered expression of ICAM-1 on thymic epithelial cells transforms selection of T cells from a diabetogenic into a neuritogenic repertoire. 108 Studies such as these highlight the critical role of regulatory mechanisms in maintaining immune homeostasis and the impact that changes to regulation can have⟳ on the development of disease.”

“Iberdomide, a cereblon modulator promoting degradation of the transcription factors Ikaros and Aiolos, which affect⟳ leukocyte development and autoimmunity, is being evaluated for the treatment of systemic lupus erythematosus (SLE).”

CEFR level