Meaning of pyrophosphorylysis | Babel Free

Definitions

The cleavage of a nucleoside from a nucleotide by breaking the bond to the phosphate group by a reaction with pyrophosphorylase.

Examples

“The enzyme preparations were assay for ADPglucose pyrophosphorylase activity in the pyrophosphorylysis direction and were diluted to 0.5 units per ml with 50 mM Tris-HCl, pH 8.0, containing O. l mg/ml of bovine plasma pyrophosphorylase.”

“Increased pyrophosphorylysis means that newly incorporated nucleotides, including potentially chain-terminating nucleotide analogues, are excised at a higher rate.”

“Although the DKAs and dihydroxypyrimidines can compete with nucleosides for binding to the active site, these compounds inhibit the pyrophosphorylysis (excision) of strand-terminating nucleosides once they are incorporated into the nascent HCV RNA.”

CEFR level