Meaning of canilicular | Babel Free

Definitions

Adjective. [C1]

Examples

“Although some studies have⟳ documented risks, 6, 7, 9 a large recent population-based study⟳ found no association of PBC with smoking, age at menarche or first pregnancy, or gravidity. 10 Prevalent coexisting autoimmune conditions include⟳ Sjögren syndrome, scleroderma, and Hashimoto thyroiditis. 4 PBC diagnosis requires two of the three following objective criteria: 1) biochemical evidence of cholestasis based primarily on elevated level of serum ALP (>1.5 times (x) the upper limit⟳ of normal, ULN); 2) presence of serum AMA (titers ≥1:40); and 3) liver histology characterized by nonsuppurative cholangitis and interlobular bile duct destruction. 3, 5, 11 AMA-positive patients with normal liver biochemistries should have⟳ yearly laboratory monitoring for the development of cholestasis. 11 In patients who are AMA negative and have⟳ liver biopsy findings of possible PBC (or PSC), genetic testing for ABCB4 (encoding the canilicular phospholipid transporter) deficiency should be considered. 11, 12 Family members (particularly female first-degree relatives) should be screened for PBC by testing serum ALP, and elevations should prompt checking AMA. 3 A small subgroup of patients demonstrates features of both PBC and autoimmune hepatitis (AIH).”

CEFR level