Meaning of aptamer | Babel Free

Definitions

Any subsequence of nucleic acid, selected from a large random sequence-pool, used to bind to a specific target molecule.

Equivalents

Examples

“Aptamers are oligomers of RNA or DNA that spontaneously fold⟳ into specific three-dimensional shapes that can bind⟳ defined targets. The specificity of the shape⟳ of the binding site arises from the base⟳ sequence of the aptamer, which determines the base-pairing pattern of the oligomer.”

“2009, Corinne Ravelet, Eric Peyrin, Chapter 10: Aptamers in Affinity Separations: Stationary Separation, Yingfu Li, Yi Lu (editors), Functional Nucleic Acids for Analytical Applications, page 271, The use⟳ of DNA or RNA aptamers as tools in analytical chemistry is a very promising field of research⟳ because of their capabilities to bind⟳ specifically the target⟳ molecules with an affinity similar to that of antibodies.”

“The field of aptamer research⟳ is also more targeted, with many more catalytic aptamers being examined rather than for binding alone.”

“2015, Caroli J et al, "APTANI: a computational tool to select⟳ aptamers through sequence-structure motif analysis of HT-SELEX data", Bioinformatics, 32 (2): 161-164, "3 Results". To test⟳ APTANI performances and validate its findings, we analyzed a sequence library corresponding to an HT-SELEX experiment⟳ designed to isolate aptamers specific for murine IL4Ra (Roth et al., 2012).”

CEFR level