Lipinski's rule of five
Definitions
A rule of thumb stating that a chemical compound is likely to be an orally active drug in humans unless it violates more than one of these criteria: (i) no more than 5 hydrogen bond donors (the total number of nitrogen–hydrogen and oxygen–hydrogen bonds); (ii) no more than 10 hydrogen bond acceptors (all nitrogen or oxygen atoms); (iii) a molecular mass less than 500 daltons; (iv) an octanol-water partition coefficient (log P) that does not exceed 5.
CEFR level
C2
Mastery
This word is part of the CEFR C2 vocabulary — mastery level.
This word is part of the CEFR C2 vocabulary — mastery level.
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